Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men.
10.3346/jkms.2004.19.3.407
- Author:
Jung Min KOH
1
;
Min Hui JUNG
;
Jeong Soo HONG
;
Hyung Joo PARK
;
Jae Suk CHANG
;
Hyoung Doo SHIN
;
Shin Yoon KIM
;
Ghi Su KIM
Author Information
1. Department of Genetic Epidemiology SNP Genetics, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
LDL-Receptor Related Proteins;
Polymorphism (Genetic);
Osteoporosis;
Bone Density;
Men
- MeSH:
Adult;
*Bone Density;
DNA Primers/chemistry;
Densitometry;
Femur/pathology;
Genotype;
Human;
Korea;
Linear Models;
Lumbar Vertebrae/pathology;
Male;
Mutation;
Polymerase Chain Reaction;
*Polymorphism (Genetics);
Polymorphism, Restriction Fragment Length;
Receptors, LDL/*genetics/metabolism;
Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science
2004;19(3):407-412
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) regulates bone formation, and that mutations of the gene cause osteoporosis-pseudoglioma syndrome or high bone mass phenotypes. However, the mutations cannot explain a genetic trait for osteoporosis in the general population because of their rarity. From 219 Korean men aged 20-34 yr, we looked for six known polymorphisms causing amino acid changes in the LRP5 coding region, and investigated their association with bone mineral density (BMD) at the following anatomical sites: lumbar spine (L2-L4) and the left proximal femur (femoral neck, Ward's triangle, trochanter and shaft). We found that the Q89R polymorphism was significantly associated with BMD at the femoral neck and Ward's triangle (p=0.004 and <0.001, respectively). However, after adjusting for age, weight and height, a statistically significant association only occurred at the Ward's triangle (p=0.043), and a marginal association was observed at the femoral neck (p=0.098). No A400V, V667M, R1036Q and A1525V polymorphisms were found, and no statistically significant association was found between the A1330V polymorphism and BMD at any sites. Although we failed to demonstrate a clear association between the LRP5 polymorphism and peak bone mass in young men, the present study suggests that larger-scale studies on the Q89R polymorphism need to be performed.
