Serum Lipid Concentrations in Croatian Veterans with Post-traumatic Stress Disorder, Post-traumatic Stress Disorder Comorbid with Major Depressive Disorder, or Major Depressive Disorder.
10.3346/jkms.2004.19.3.431
- Author:
Dalibor KARLOVIC
1
;
Danijel BULJAN
;
Marko MARTINAC
;
Darko MARCINKO
Author Information
1. University Department of Psychiatry, "Sestre milosrdnice" University Hospital, Vinogradska cestra 29, Zagreb, Croatia. dalibor.karlovic@zg.hinet.hr
- Publication Type:Original Article
- Keywords:
Croatia;
Cholesterol;
Lipoproteins, LDL;
Lipoproteins, HDL;
Triglycerides;
Stress Disorder, Post-traumatic;
Major Depressive Disorder;
Depression, Involutional
- MeSH:
Adult;
Blood Pressure;
Body Mass Index;
Cholesterol/blood;
Combat Disorders;
Croatia;
Depression/*blood/*complications;
Human;
Lipids/*metabolism;
Male;
Middle Aged;
Stress Disorders, Post-Traumatic/*blood/*complications;
Veterans
- From:Journal of Korean Medical Science
2004;19(3):431-436
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to assess eventual differences in serum cholesterol, low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDLC), triglycerides, LDL-C/HDL-C ratio between veterans with combat-related posttraumatic stress disorder (PTSD) only or comorbid with major depressive disorder (MDD), veterans with combat experiences with MDD, and healthy control group. PTSD and/ or MDD were diagnose according to structured clinical interview based on DSM-IV criteria. Additional criteria to diagnose PTSD were Clinician Administered PTSD Scale (CAPS), and to diagnose MDD Montgomery-Asberg Depression Rating Scale (MADRAS). Serum lipid concentrations were determined by using the enzyme-assay method. Veterans with combat-related PTSD as well as veterans with combat-related PTSD comorbid with MDD showed significantly higher concentrations of cholesterol (F=9.858, p<0.01), triglycerides (F=10.112, p<0.01), LDL-C (F=11.145, p<0.01), and LDL-C/HDL-C ratio (F=8.346, p<0.01) vs. veterans with MDD or healthy control group. Contrary healthy control group and veterans with MDD showed significantly higher concentrations of HDL-C (F=8.421, p<0.01), vs. veterans with PTSD or PTSD comorbid with MDD. In conclusion, there are no differences in serum lipid concentrations between veterans with combat-related PTSD and PTSD comorbid with MDD, but they have higher lipid concentrations than veterans with MDD or healthy control subjects.
