Severe Chronic Active EBV Infection in an Adult Patient: Case Report.
10.3346/jkms.2004.19.3.453
- Author:
Sang Yoon HA
1
;
Chul Won CHUNG
;
Young H KO
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea. yhko@smc.samsung.co.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Herpesvirus 4, Human;
Chronic Active Infection
- MeSH:
Antigens, CD3/biosynthesis;
Antigens, CD4/biosynthesis;
Antigens, CD8/biosynthesis;
Bone Marrow Cells/virology;
Epstein-Barr Virus Infections/*diagnosis/*mortality;
Female;
Herpesvirus 4, Human/genetics;
Human;
Immunohistochemistry;
Lymph Nodes/virology;
Lymphocytes/metabolism;
Middle Aged;
Organ Weight;
Spleen/pathology/virology;
Support, Non-U.S. Gov't;
T-Lymphocytes/virology
- From:Journal of Korean Medical Science
2004;19(3):453-457
- CountryRepublic of Korea
- Language:English
-
Abstract:
Severe chronic active Epstein-Barr virus (EBV) infection is a rare and life-threatening illness. Although the criteria for diagnosis include chronic or recurrent infectious mononucleosis-like symptoms lasting more than 6 months and high titers of anti-EBV antibodies, clinical and laboratory findings may be heterogeneous and flexible application of those criteria is necessary in cases showing typical clinical and pathologic findings. We report a case of severe chronic active EBV infection in a 62-yr-old female patient who showed classical clinical findings with infiltration of EBV-infected T lymphocytes in the bone marrow, spleen, and lymph nodes, and died four months after presentation.
