Susceptibilities to Azoles of Candida albicans in Vulvovaginal Candidiasis.
- Author:
Kye Hyun KIM
1
;
Tae Hyoung KIM
;
Mi Kyung LEE
Author Information
1. Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Recurrent vulvovaginal candidiasis;
Candida albicans;
Azole susceptibility
- MeSH:
Azoles;
Candida;
Candida albicans;
Candidiasis, Vulvovaginal;
Danazol;
Fluconazole;
Humans;
Itraconazole;
Pyrimidines;
Recurrence;
Treatment Failure;
Triazoles;
Vulvovaginitis
- From:Korean Journal of Medical Mycology
2011;16(1):24-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There are limited data regarding the antifungal susceptibility of Candida albicans causing recurrent vulvovaginal candidiasis. OBJECTIVE: The aim of the present study was to evaluate the effect of azoles susceptibilities on treatment failure and recurrence of vulvovaginal candidiasis. METHODS: Species identification was performed on 84 vaginal Candida isolates collected from October 2008 to June 2010 from 404 patients with suspected vulvovaginitis. MICs of C. albicans (26 isolates) to fluconazole, itraconazole, and voriconazole were tested by broth microdilution method of the Clinical and Laboratory Standards Institute (CLSI) M27-A2. RESULTS: C. albicans was the most frequently isolated (88.1%). All isolates were susceptible to fluconazole, itraconazole, and voriconazole. Trailing growth was found in treatment success group (10.0%) and treatment failure group (33.3%). CONCLUSIONS: The results of this study suggest the possibility that trailing growth have influence on treatment failure of vulvovaginal candidiasis.
