Predictive Significance of Serum IL-6, VEGF, and CRP in Gastric Adenoma and Mucosal Carcinoma before Endoscopic Submucosal Dissection.
- Author:
Jin Seok JANG
1
;
Seok Reyol CHOI
;
Sang Young HAN
;
Myung Hwan ROH
;
Jong Hoon LEE
;
Sung Wook LEE
;
Jin Sook JEUNG
;
Min Chan KIM
;
Young Ki SON
;
Yang Hyun BAEK
Author Information
- Publication Type:Original Article ; English Abstract
- Keywords: Serum IL-6; VEGF; CRP; Adenoma; Cancer
- MeSH: Adenoma/*diagnosis/pathology/surgery; Adult; Aged; C-Reactive Protein/*analysis; Carcinoma/*diagnosis/pathology/surgery; Diagnosis, Differential; Female; Gastric Mucosa/*surgery; Gastroscopy; Humans; Interleukin-6/*blood; Male; Middle Aged; Predictive Value of Tests; Stomach Neoplasms/*diagnosis/pathology/surgery; Vascular Endothelial Growth Factors/*blood
- From:The Korean Journal of Gastroenterology 2009;54(2):99-107
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resecwas to clarify the clinical significance of IL-6, VEGF, CRP before ESD. METHODS: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers). RESULTS: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05). Especially, serum IL-6 level of high-grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients, and the positive rate, sensitivity, and negative predictive value of serum IL-6 levels were higher in high-grade dysplasia patient compared to low-grade dysplasia patient and mucosal cancer patient. Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01). Serum levels of CRP in patients with mucosal cancer were significantly higher than in the controls (p<0.05), and the positive rate, sensitivity, and positive predictive value of serum CRP levels were higher in high-grade dysplasia and mucosal cancer patients compared to low-grade dysplasia patient. CONCLUSIONS: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients.
