Efficacy of Infliximab in the Treatment of Korean Patients with Crohn's Disease.
10.4166/kjg.2009.54.2.108
- Author:
Sai Hui KIM
1
;
Suk Kyun YANG
;
Kyung Jo KIM
;
Eun Hee KIM
;
Soon Man YOON
;
Byong Duk YE
;
Jeong Sik BYEON
;
Seung Jae MYUNG
;
Jin Ho KIM
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. sky@amc.seoul.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Inflammatory bowel disease;
Crohn's disease;
Infliximab
- MeSH:
Adolescent;
Adult;
Antibodies, Monoclonal/*therapeutic use;
Asian Continental Ancestry Group;
Crohn Disease/*drug therapy;
Female;
Fistula/*drug therapy;
Humans;
Immunosuppressive Agents/*therapeutic use;
Korea;
Male;
Middle Aged;
Retrospective Studies;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2009;54(2):108-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Infliximab has been proven to be effective for refractory luminal and fistulizing Crohn's disease (CD). We performed this study to demonstrate the efficacy of infliximab in Korean CD patients. METHODS: Medical records of 40 CD patients who had been treated with infliximab were reviewed retrospectively. RESULTS: Among 40 patients, 11 (27.5%) patients were treated for refractory luminal disease, 14 (35%) for fistulizing disease, and 15 (37.5%) for both types. Clinical response rate was higher in 26 patients with refractory luminal disease (Complete response (CR), 73.1%; Partial response (PR), 23.1%) than in 29 patients with fistulizing disease (CR, 41.4%; PR, 31%) (p=0.024). The clinical response rate tended to be higher in 28 patients with external fistulas (CR, 46.4%; PR, 32.2%) than 4 patients with internal fistulas (PR, 25%; NR, 75%) (p=0.064). Among patients with external fistulas, the response rate of 8 patients with enterocutaneous fistulas (CR, 50%; PR, 12.5%) was not different from 20 patients with perianal fistulas (CR, 45%; PR, 40%). Among 20 patients with perianal fistulas, the response rate of 6 patients with perianal fistulas without a history of operation (CR, 83.3%; PR, 0%) was higher than 14 patients with perianal fistulas resistant to previous surgical treatment (CR, 28.6%; PR, 57.1%) (p=0.044). As for adverse reaction, 7 patients experienced mild infusion reaction, and 2 patients developed serious infection. CONCLUSIONS: Infliximab is more effective for refractory luminal disease than for fistulizing disease. In addition, clinical responses to infliximab are different according to subtypes of fistulas. These findings should be considered for the proper use of infliximab.
