The Efficacy of Short-term Administration of Revaprazan on Gastroesophageal Reflux Symptoms: Comparison with Half Dose Esomeprazole, a Pilot Study.
10.7704/kjhugr.2012.12.1.23
- Author:
Hae Mi LEE
1
;
Byung Wook KIM
;
Joon Sung KIM
;
Eun Joo IM
;
Jong In KIM
;
Bong Koo KANG
;
Jeong Seon JI
;
Bo In LEE
;
Hwang CHOI
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea. gastro@catholic.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Revaprazan;
Esomeprazole;
Gastroesophageal reflux
- MeSH:
Endoscopy, Digestive System;
Esomeprazole Sodium;
Gastric Acid;
Gastritis;
Gastroesophageal Reflux;
Humans;
Peptic Ulcer;
Pilot Projects;
Pyrimidinones;
Tetrahydroisoquinolines;
Surveys and Questionnaires
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2012;12(1):23-26
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Revaprazan, an acid pump antagonist, is a kind of gastric acid suppressant and is prescribed for the treatment of peptic ulcers and gastritis. However, the efficacy of revaprazan on gastroesophageal reflux symptoms has not been established. The aim of this study was to evaluate the short-term efficacy of revaprazan on gastroesophageal reflux symptoms. MATERIALS AND METHODS: Patients who complained of gastroesophageal reflux symptoms without any specific diseases except gastritis on esophagogastroduodenoscopy were included in this study. Patients were randomized to receive revaprazan 200 mg or esomeprazole 20 mg for 2 weeks. Symptoms were assessed by using the frequency score questionnaire before and after treatment. RESULTS: Fifteen patients received revaprazan and 19 patients received esomeprazole. The changes of the symptom frequency score before and after treatment were 7.0 in revaprazan group and 8.6 in esomeprazole group (P=0.778). CONCLUSIONS: Revaprazan is not inferior to esomeprazole in therapeutic efficacy for gastroesophageal reflux symptoms and is a safe and useful therapeutic agent to reduce the frequency of gastroesophageal reflux symptoms.
