Atypical Nodule Arising in a Hepatocellular Adenoma.
- Author:
Kun Chang SONG
;
Young Nyun PARK
;
Chanil PARK
- Publication Type:Original Article
- Keywords:
Liver;
Hepatocellular adenoma;
Atypical nodule within a nodule;
Hepatocellular carcinoma
- MeSH:
Carcinoma, Hepatocellular
- From:Korean Journal of Pathology
1995;29(2):251-255
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This report presents a case of an atypical nodule arising in a hepatocellular adenoma(HCA) in a non-cirrhotic liver of a 42-year-old man. The patient had been relatively healthy until he developed right upper abdominal pain. Abdominal sonography and computerized tomogram revealed a 7.5x7cm sized mass in the right inferior segment of liver. The mass revealed the histologic features of HCA. At near center of the HCA, was found a I cm sized discrete nodule, a nodule within a nodule. The nodule revealed higher cellularity than the HCA and was composed of monotonous hepatocytes with an increased nuclear-cytoplasmic ratio, resembling atypical adenomatous hyperplasia. Interestingly, the atypical nodule showed a focal pseudoacinar arrangement of tumor cells. The histologic features of the atypical nodule arising in HCA may the morphological sequence of transformation from HCA to hepatocellular carcinoma
