The Effect of Desmopressin in Neurogenic Bladder due to Spinal Cord in Jury.
- Author:
Jae Gyun SO
1
;
Won Hee PARK
;
Hong Bang SHIM
Author Information
1. Department of Urology, Korae Veterans Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Desmopressin;
Spinal cord injury;
Neurogenic bladder
- MeSH:
Deamino Arginine Vasopressin*;
Enuresis;
Estrogens, Conjugated (USP);
Humans;
Nocturia;
Nocturnal Enuresis;
Spinal Cord Injuries;
Spinal Cord*;
Thorax;
Urinary Bladder, Neurogenic*
- From:Korean Journal of Urology
1998;39(1):61-64
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Nocturia and enuresis are common voiding problems in spinal cord injured patients despite a variety of management. The purpose of this study is to determine the efficacy of desmopressin, a synthetic analogue of antidiuretic mono, as an alternative treatment in the management of spinal cord injured(SCI) patients with neurogenic bladder dysfunction unresponsive to conventional therapy. MATERIALS AND METHODS: Fourteen SCI patients with nocturia or enuresis were included in this study. The patients received 10microgram desmopressin intranasally at bedtime once every 24 hours. RESULTS: There was a significant decrease in nocturnal urinary volume, frequency of nocturia and nocturnal enuresis during nighttime after desmopressin administration. Two patients stopped desmopressin because of side effects. 8 of 12 patients improved with desmopressin and the remainder had no effect. There was no serum abnormality, although there were side effects in three cases, such as gastro-intestinal trouble, chest discomfort or nasal congestion. CONCLUSIONS: Desmopressin is safe and effective in the management of nocturia or enuresis due to neurogenic bladder dysfunction in selected SCI patients.
