The Open Artery Hypothesis.
10.4070/kcj.2007.37.6.235
- Author:
Chul Min KIM
1
Author Information
1. Cardiology Division, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. cmkim@vincent.cuk.ac.kr
- Publication Type:Review
- Keywords:
Myocardial infarction;
Reperfusion;
Ventricular remodeling
- MeSH:
Arrhythmias, Cardiac;
Arteries*;
Humans;
Myocardial Infarction;
Myocardium;
Reperfusion;
Ventricular Remodeling
- From:Korean Circulation Journal
2007;37(6):235-243
- CountryRepublic of Korea
- Language:English
-
Abstract:
There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development of ventricular remodeling, and decreases ventricular arrhythmia. The Occluded Artery Trial recently answered a major question related to the open artery hypothesis in a high-risk, asymptomatic patient with an occluded infarct artery. In this review, clinical and experimental evidence of the benefit of the open artery hypothesis will be discussed.
