Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women.
10.4070/kcj.2007.37.6.251
- Author:
Kihwan KWON
1
;
Kyungsun CHOI
;
Si Hoon PARK
Author Information
1. Cardiovascular Center, Department of Internal Medicine, Ewha Womans University, School of Medicine, Seoul, Korea. kankadin@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Endothelium;
Vascular;
Leptin;
Obesity
- MeSH:
Adipokines;
Adiponectin;
Albuterol;
Body Mass Index;
C-Reactive Protein;
Endothelium;
Fasting;
Female;
Glucose;
Humans;
Immunoenzyme Techniques;
Insulin;
Leptin*;
Obesity;
Plasma;
Pulse Wave Analysis;
Resistin;
Risk Factors;
Tumor Necrosis Factor-alpha;
Vasodilation
- From:Korean Circulation Journal
2007;37(6):251-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women. SUBJECTS AND METHODS: Noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol was used to measure endothelium-dependent vasodilation in 60 healthy premenopausal women [37 obese women; body mass index (BMI) > or = 25 kg/m2, 23 age-matched non-obese women; BMI<25 kg/m2]. The lipid profile, fasting insulin, glucose, and C-reactive protein (CRP) concentrations in each patient were assessed via standard laboratory techniques, and plasma concentrations of various adipokines, such as adiponectin, leptin, resistin and TNF-alpha, were measured via enzyme immunoassays. RESULTS: In the obese group, higher leptin concentrations were significantly associated with impairments in endothelium-dependent vasodilation (r=-0.371, p=0.005). This association remained significant, even after adjustment for other risk factors (beta=-0.39, p=0.006). However, we determined that there was no significant correlation between endothelium-dependent vasodilation and these variables in the obese group and the control group. CONSLUSION: Increased plasma concentration of leptin was associated with impairment in endothelial function in obese premenopausal women, regardless of the metabolic and inflammatory disturbances associated with obesity.
