Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages.
10.3347/kjp.2014.52.6.695
- Author:
Moses T BILITY
1
;
Banchob SRIPA
Author Information
1. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA. moses_bility@med.unc.edu
- Publication Type:Brief Communication ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
- Keywords:
Opisthorchis viverrini;
M2-like macrophage;
iron;
hepatobiliary fibrosis;
cancer
- MeSH:
Animals;
Cricetinae;
Gene Expression Profiling;
Histocytochemistry;
Humans;
Immunohistochemistry;
Iron/*metabolism;
Liver Cirrhosis/*parasitology/*pathology;
Macrophages/*immunology/metabolism;
Mesocricetus;
Opisthorchiasis/*complications/*pathology;
Opisthorchis/*isolation & purification
- From:The Korean Journal of Parasitology
2014;52(6):695-699
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
