Changes in Muscular Lipids in Unilateral Isolated Hypertrophy of Gastrocnemius Muscle Can Be Revealed by 1H MR Spectroscopy.
10.3348/kjr.2009.10.6.581
- Author:
Klaus BRECHTEL
1
;
Juergen MACHANN
;
Margarete PICK
;
Juergen F SCHAEFER
;
Claus D CLAUSSEN
;
Fritz SCHICK
Author Information
1. Section on Experimental Radiology, Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany. fritz.schick@med.uni-tuebingen.de
- Publication Type:Case Reports
- Keywords:
EMCL;
Muscle hypertrophy;
Magnetic resonance spectroscopy;
Extramyocellular lipids;
Intramyocellular lipids
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Female;
Humans;
Hypertrophy/metabolism;
Leg/pathology;
*Lipid Metabolism;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy/*methods;
Muscle, Skeletal/*metabolism/pathology
- From:Korean Journal of Radiology
2009;10(6):581-586
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To test whether proton magnetic resonance spectroscopy (1H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM. MATERIALS AND METHODS: 1H-MRS was performed on a 1.5 Tesla (T) whole-body unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers. RESULTS: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg. CONCLUSION: Muscular lipids are substrates for metabolism and can be assessed non-invasively by 1H-MRS. 1H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.
