The Effect of Cyanidin-3-O-beta-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction.
10.5534/kja.2011.29.2.127
- Author:
U Syn HA
1
;
Joon Sung KOH
;
Jang Chun WOO
;
Suk Ju KIM
;
Su Jin KIM
;
Hoon JANG
;
Byung Il YOON
;
Seong Yeon HWANG
;
Sae Woong KIM
Author Information
1. Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea. ksw1227@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Cyanidin-3-O-beta-d-glucopyranoside;
Diabetes Mellitus;
Erectile dysfunction
- MeSH:
Animals;
Diabetes Mellitus;
Erectile Dysfunction;
Male;
Penile Erection;
Rats;
Rats, Sprague-Dawley;
Streptozocin;
Water
- From:Korean Journal of Andrology
2011;29(2):127-133
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to evaluate Cyanidin-3-O-beta-d-glucopyranoside on improvement and protection for erectile function. MATERIALS AND METHODS: Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each): normal control, diabetes (DM), and diabetes with Cyanidin-3-O-beta-d-glucopyranoside (C3G) concentration materials treatment (DM+C3G). DM and DM+C3G group received a single injection of streptozotocin (50 mg/kg), and 4 wk after induction of diabetes, DM+C3G group were treated with daily C3G (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled. RESULTS: DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM+C3G group showed improved erectile function by minimizing corporal apoptosis. CONCLUSIONS: The current study is the first to suggest that Cyanidin-3-O-beta-d-glucopyranoside may have a potency to improve and protect erectile function in a rat model of diabetic erectile dysfunction.
