Restoration of P-glycoprotein function is involved in the increase of natural killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals.
10.3349/ymj.2000.41.5.600
- Author:
Kyung Hee CHANG
1
;
June Myung KIM
;
Nae Choon YOO
;
Won Ho KIM
;
Jeon Han PARK
;
In Hong CHOI
;
Hyun Sook KIM
;
Kyung Won LEE
;
Young Goo SONG
;
Sung Kwan HONG
;
Hyo Yeul KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jmkim@yumc.yonsei. ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Interleukin-15;
NK cells;
NK activity;
HIV;
P-glycoprotein
- MeSH:
HIV Infections/physiopathology*;
HIV Infections/pathology;
Human;
Interleukin-15/pharmacology*;
Killer Cells, Natural/physiology*;
Killer Cells, Natural/drug effects*;
P-Glycoprotein/physiology*;
Recombinant Proteins/pharmacology
- From:Yonsei Medical Journal
2000;41(5):600-606
- CountryRepublic of Korea
- Language:English
-
Abstract:
A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1alpha (MCP-1alpha) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.
