Clinical Review of Toxic Alcohol Poisoning Cases in Korea.
- Author:
Nu Ga RHEE
1
;
Sung Phil CHUNG
;
In Cheol PARK
;
Kyeong Ryong LEE
;
Hyun Jin KIM
;
Gun Bea KIM
;
Young Soon CHO
;
In Ho KWON
;
Seung Whan KIM
Author Information
1. Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea. emstar@yuhs.ac
- Publication Type:Original Article
- Keywords:
Poisoning;
Methanol;
Ethylene glycol;
Toxic alcohol
- MeSH:
2-Propanol;
Acid-Base Equilibrium;
Acidosis;
Alcohol Dehydrogenase;
Alcohols;
Emergencies;
Ethanol;
Ethylene Glycol;
Ethylenes;
Humans;
Korea;
Medical Records;
Methanol;
Renal Dialysis;
Retrospective Studies;
Stress, Psychological;
Suicide
- From:Journal of The Korean Society of Clinical Toxicology
2012;10(1):15-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Toxic alcohols are responsible for accidental and suicide motivated poisonings, resulting in death or permanent sequelae for the afflicted patients. Major therapeutic modalities in these cases include treatment with alcohol dehydrogenase inhibitors and extracorporeal elimination. There have been a number of case reports of toxic alcohol intoxication in Korea. The purpose of this study was to review the clinical characteristics of patients suffering toxic alcohol intoxication. METHODS: We retrospectively reviewed the medical records of patients who presented with toxic alcohol intoxication at 8 emergency departments (ED) from Jun 2005 to Nov 2011. Patients who ingested methanol, isopropyl alcohol, ethylene glycol, and other alcohols except ethanol, were included in this study. The clinical characteristics of these patients were analyzed to include anion and osmolar gap, and estimated concentration of alcohol in the body. RESULTS: During the study period, 21 patients were identified who had ingested toxic alcohol (methanol; 12 patients, ethylene glycol; 9 patients). At ED arrival, the mean anion gap was 18.7+/-6.9 and the osmolar gap was elevated in 13 patients. Oral and IV ethanol were administrated to 11 patients in order to inhibit alcohol dehydrogenase. Extracorporeal elimination procedures such as hemodialysis were performed in 9 patients. There were no fatalities, but the one patient suffered permanent blindness. CONCLUSION: This study found that ethylene glycol and methanol were the substances ingested which produced toxic alcohol intoxication. The patients presented with high anion gap metabolic acidosis and were typically treated with oral ethanol and hemodialysis.
