Clinicopathologic Characteristics of Left-Sided Colon Cancers with High Microsatellite Instability.
10.4132/KoreanJPathol.2009.43.5.428
- Author:
Sang Kyum KIM
1
;
Junjeong CHOI
;
Hyun Ki KIM
;
Young Nyun PARK
;
Si Young SONG
;
Hoguen KIM
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. hkyonsei@yuhs.ac
- Publication Type:Original Article
- Keywords:
Colorectal neoplasm;
Microsatellite instability;
Colorectal neoplasms, hereditary nonpolyposis
- MeSH:
Adenocarcinoma, Mucinous;
Calcium Hydroxide;
Colon;
Colonic Neoplasms;
Colorectal Neoplasms;
Colorectal Neoplasms, Hereditary Nonpolyposis;
Microsatellite Instability;
Microsatellite Repeats;
Mucins;
Zinc Oxide
- From:Korean Journal of Pathology
2009;43(5):428-434
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: High microsatellite instability (MSI-H) colorectal carcinomas (CRCs) with numerous mutations in the microsatellite sequence are characterized by a right-sided preponderance, frequent peritumoral and intratumoral lymphocytic infiltration, and frequent mucin production. However, no study has correlated anatomic site and type of genetic changes with clinicopathologic changes. METHODS: We analyzed the histopathologic features of 135 MSI-H CRCs and compared them to 140 microsatellite stable (MSS) CRCs. Histopathologic changes in MSI-H were further analyzed according to anatomic sites and genetic changes. RESULTS: MSI-H CRCs showed previously reported clinicopathologic findings; a right-sided preponderance, an increased number of mucinous carcinomas, and peritumoral lymphoid reactions (p<0.001 for each variable). Increased serum CEA levels showed an MSS CRC preponderance (p=0.013). We further analyzed the histologic differences between right- and left-sided MSI-H tumors. We found that MSI-H CRCs on both sides had similar clinicopathologic findings, except for higher tumor stage (p=0.048) and less frequent abnormal CEA levels in left-sided MSI-H tumors (p=0.027). We found that not all clinicopathologic features were different between hereditary nonpolyposis colorectal cancers (HNPCCs) and sporadic MSI-H CRCs. CONCLUSIONS: These findings indicate that MSI-H CRCs of the left colon have similar clinicopathologic characteristics as right-sided MSI-H CRCs. We did not find any significant clinicopathological difference between HNPCCs and sporadic MSI-H CRCs.
