Effect of isoflurane versus propofol-remifentanil anesthesia on neuromuscular blockade and hemodynamic responses by cisatracurium bolus injection.
10.4097/kjae.2011.61.4.297
- Author:
Dongho HYUN
1
;
Han Bom RYU
;
Mi Woon KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Gyeongju Hospital, College of Medicine, Dongguk University, Gyeongju, Korea. swankim@dongguk.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Cisatracurium;
Isoflurane;
Propofol;
Remifentanil
- MeSH:
Anesthesia;
Anesthesia, Intravenous;
Anesthetics;
Atracurium;
Blood Pressure;
Heart Rate;
Hemodynamics;
Humans;
Intubation;
Isoflurane;
Korea;
Muscles;
Neuromuscular Blockade;
Piperidines;
Propofol
- From:Korean Journal of Anesthesiology
2011;61(4):297-301
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Inhalational anesthetics potentiate nondepolarizing muscle relaxants. Cisatracurium is a recently introduced neuromuscular blocker in Korea. We studied the effect of inhalational anesthesia and total intravenous anesthesia (TIVA) on neuromuscular blockades and hemodynamic responses by cisatracurium bolus injection. METHODS: Forty patients undergoing elective surgery were randomly divided into isoflurane and propofol-remifentanil groups. A bolus dose of cisatracurium of 0.15 mg/kg (3 x ED95) was administered after induction and the onset time and clinical duration of action were recorded. The nueromuscular blockade was monitored using train-of-four (TOF) stimulation. Hemodynamic parameters were also recorded. RESULTS: Onset time was 194.0 +/- 39.1 sec in the isoflurane group and 226.5 +/- 62.2 sec in the propofol-remifentanil group. Clinical duration of action was 49.2 +/- 9.0 min in the isoflurane group and 43.0 +/- 9.2 min in the propofol-remifentanil group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) immediately before intubation decreased in the propofol-remifentanil group. Heart rate (HR), SBP and DBP 1 and 3 min after tracheal intubation increased in the isoflurane group. CONCLUSIONS: Onset time was similar between isoflurane and propofol-remifentanil anesthesia. Clinical duration of action was significantly longer in isoflurane anesthesia. SBP and DBP immediately before intubation and HR, SBP and DBP 1 and 3 min after tracheal intubation were significantly different between the two groups.
