Fatal Hemophagocytic Lymphohistiocytosis associated with Influenza B.
- Author:
Saem Na LEE
1
;
Jin Gu YOON
;
Chi Hyun CHO
;
Chul Won CHOI
;
Jung Yoon CHOI
;
Hee Jin CHEONG
;
Woo Joo KIM
Author Information
- Publication Type:Case Report
- Keywords: Influenza B; Lymphohistiocytosis, Hemophagocytic
- MeSH: Diagnosis; Early Diagnosis; Hospitalization; Humans; Influenza, Human*; Lymphocytes; Lymphohistiocytosis, Hemophagocytic*; Macrophages; Male
- From:Korean Journal of Medicine 2016;91(1):88-91
- CountryRepublic of Korea
- Language:Korean
- Abstract: Influenza infection may be complicated by various infectious or non-infectious diseases. Among them, hemophagocytic lympho-histiocytosis (HLH) is an uncommon hyperinflammatory syndrome caused by uncontrolled proliferation and activation of macrophages and lymphocytes, and it is often life threatening. A previously healthy male patient was suspected to have HLH after influenza B infection. The diagnosis was established based on clinical diagnostic criteria suggested in the HLH-2004 trial. Despite prompt antiviral therapy, the patient expired on day 19 of hospitalization. Influenza can thus be complicated by HLH. Due to the non-specific manifestations of HLH, clinical suspicion and early diagnosis are important.
