Aggressive surgical resection for concomitant liver and lung metastasis in colorectal cancer.
10.14701/kjhbps.2016.20.3.110
- Author:
Sung Hwan LEE
1
;
Sung Hyun KIM
;
Jin Hong LIM
;
Sung Hoon KIM
;
Jin Gu LEE
;
Dae Joon KIM
;
Gi Hong CHOI
;
Jin Sub CHOI
;
Kyung Sik KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. kskim88@yuhs.ac
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
Liver cancer;
Lung cancer;
Metastasis
- MeSH:
Colorectal Neoplasms*;
Humans;
Liver Neoplasms;
Liver*;
Lung Neoplasms;
Lung*;
Neoplasm Metastasis*;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2016;20(3):110-115
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUNDS/AIMS: Aggressive surgical resection for hepatic metastasis is validated, however, concomitant liver and lung metastasis in colorectal cancer patients is equivocal. METHODS: Clinicopathologic data from January 2008 through December 2012 were retrospectively reviewed in 234 patients with colorectal cancer with concomitant liver and lung metastasis. Clinicopathologic factors and survival data were analyzed. RESULTS: Of the 234 patients, 129 (55.1%) had synchronous concomitant liver and lung metastasis from colorectal cancer and 36 (15.4%) had metachronous metastasis. Surgical resection was performed in 33 patients (25.6%) with synchronous and 6 (16.7%) with metachronous metastasis. Surgical resection showed better overall survival in both groups (synchronous, p=0.001; metachronous, p=0.028). In the synchronous metastatic group, complete resection of both liver and lung metastatic lesions had better survival outcomes than incomplete resection of two metastatic lesions (p=0.037). The primary site of colorectal cancer and complete resection were significant prognostic factors (p=0.06 and p=0.003, respectively). CONCLUSIONS: Surgical resection for hepatic and pulmonary metastasis in colorectal cancer can improve complete remission and survival rate in resectable cases. Colorectal cancer with concomitant liver and lung metastasis is not a poor prognostic factor or a contraindication for surgical treatments, hence, an aggressive surgical approach may be recommended in well-selected resectable cases.
