EDTA-dependent Pseudothrombocytopenia Confirmed by Supplementation of Kanamycin: A Case Report.
- Author:
Hae Lyun AHN
1
;
Young Il JO
;
Young Suk CHOI
;
Jung Yeon LEE
;
Hae Woon LEE
;
Seong Ryul KIM
;
Joon SIM
;
Weon LEE
;
Chun Jo JIN
Author Information
1. Department of Internal Medicine Konkuk University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Pseudothrombocytopenia;
EDTA;
Platelet aggregation;
Kanamycin
- MeSH:
Antibiotics, Aminoglycoside/*pharmacology;
Anticoagulants/*adverse effects/pharmacology;
Case Report;
Edetic Acid/*adverse effects;
Female;
Human;
Kanamycin/*pharmacology;
Middle Age;
Platelet Aggregation/*drug effects;
Platelet Aggregation Inhibitors/*therapeutic use;
Platelet Count;
Thrombocytopenia/*blood/chemically induced
- From:The Korean Journal of Internal Medicine
2002;17(1):65-68
- CountryRepublic of Korea
- Language:English
-
Abstract:
EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.
