Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand.
10.3802/jgo.2015.26.4.293
- Author:
Siriwan TANGJITGAMOL
1
;
Jakkapan KHUNNARONG
;
Sunamchok SRIJAIPRACHAROEN
Author Information
1. Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand. siriwanonco@yahoo.com
- Publication Type:Original Article
- Keywords:
Endometrial Cancer;
Non-endometrial Cancers;
Metachronous, Synchronous
- MeSH:
Breast Neoplasms/mortality/pathology/therapy;
Chemotherapy, Adjuvant/methods;
Colonic Neoplasms/mortality/pathology/therapy;
Disease-Free Survival;
Endometrial Neoplasms/mortality/*pathology/therapy;
Female;
Humans;
Kaplan-Meier Estimate;
Middle Aged;
Neoplasm Recurrence, Local/mortality;
Neoplasms, Multiple Primary/mortality/*pathology/therapy;
Neoplasms, Second Primary/mortality/*pathology/therapy;
Radiotherapy, Adjuvant/methods;
Tertiary Care Centers/statistics & numerical data;
Thailand/epidemiology
- From:Journal of Gynecologic Oncology
2015;26(4):293-302
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS: EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death. RESULTS: The mean age of the 344 patients was 56.8+/-10.8 years. Fifty (14.5%) had other synchronous and metachronous cancers. Mean ages of the patients with or without other cancers were not significantly different, 55.7+/-10.04 years versus 57.1+/-11.0 years, respectively (p=0.358). History of any cancer in the family and tumor in the lower uterine segment were more frequent among the patients with other cancers (6.0% vs. 1.7%, p=0.095; 12.0% vs. 1.0%, p<0.001; respectively). Six patients had > or =2 other cancers. Ovarian, breast, and colon were the three most common other cancers. After a median follow-up of 57.1 months, 18.3% of patients had died: 30.0% of patients with other cancers and 16.3% of those without other cancers. The corresponding EC deaths were 14.0% and 11.2%. The 5-year overall survival was significantly lower in patients who had other cancers: 79.3% (95% confidence interval [CI], 68.3 to 90.3) vs. 86.0% (95% CI, 81.7 to 90.3) than in those without (p=0.023). However, the corresponding disease-specific survival was not significantly different: 85.1% (95% CI, 75.5 to 94.7) compared with 89.0% (95% CI, 85.1 to 92.9), respectively (p=0.514). CONCLUSION: Thai EC patients had a high incidence of other cancers. Overall survival of EC patients who had other cancers was worse than those without, while disease-specific survival was not significantly different.
