TEG Assessment of The Effect of Tranexamic Acid on Fibrinolysis during Open Heart Surgery.
10.4097/kjae.1996.31.5.634
- Author:
Chee Man SHIN
1
;
Joong Lae KIM
;
Yeong Gyun CHOE
;
Yeong Jae KIM
;
Jin Woo PARK
;
Ju Yeol PARK
Author Information
1. Department of Anesthesiology, Collage of Medicine, University of Inje, Pusan, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Blood fibrinolysis;
Equipment thromboelastograph;
Heart cardiopulmonary bypass
- MeSH:
Catheterization;
Fibrin Fibrinogen Degradation Products;
Fibrinolysis*;
Heart*;
Hemorrhage;
Humans;
Thoracic Surgery*;
Thrombelastography;
Tranexamic Acid*
- From:Korean Journal of Anesthesiology
1996;31(5):634-639
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Activated fibrinolysis during cardiopulmonary bypass(CPB) is one of the causes of post CPB coagulopathy. Antifibirinolytics such as tranexamic acid have been administered prophylactically before CPB to decrease postCPB bleeding. However, their routinely application has been challenged as regarding it's thrombotic complication. This study was performed to evaluate the effect of tranexamic acid administered before CPB by thromboelastography. METHODS: 50 open heart surgical patients were randomly selected and devided into two groups, control(N=25) and tranexamic acid group(N=25). In tranexamic acid group. 125mg of tranexamic acid were singly infused before vena caval and aortic cannulation. All of parameters of thromboelastography (TEG) and fibrin degradation products measured before and after CPB were compared between two groups. RESULTS: There were no significant differences in fibrinolytic indexes of TEGs between control group and tranexamic group afte CPB. And there were also no changes in fibrinolysis index between before and after CPB in both groups. The concentration of FDP did not changed after CPB in both groups. CONCLUSIONS: It may be considered that prophylactic administration of tranexamic acid before CPB to reduce post-CPB bleeding would not be recommended routinely.
