Experimental Study on the Rim-Enhancing Lesion of Rabbit Brain Abscess: MR Imaging and Histopathologic Correlation.
10.3348/jkrs.1996.35.5.651
- Author:
Hee Jung LEE
1
;
Soo Jhi SUH
;
Sang Pyo KIM
;
Yang Goo JOO
;
Seok Kil ZEON
;
Seong Ku WOO
Author Information
1. Department of Diagnostic Radiology, Keimyung University School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Animals;
Brain, abscess;
Brain, MR;
Magnetic resonance(MR), contrast enhancement
- MeSH:
Abscess;
Animals;
Brain Abscess*;
Brain*;
Collagen;
Granulation Tissue;
Hemosiderin;
Magnetic Resonance Imaging*;
Rabbits;
Reticulin;
Staphylococcus aureus
- From:Journal of the Korean Radiological Society
1996;35(5):651-659
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate on the basis of histopathologic carrelation the MR findings of mature brain abscess inthe rabbit, with particular attention to rim-enhancing lesions. MATERIALS AND METHODS: The evolution of abscess formation was obtained by the direct inoculation of Staphylococcus aureus into the gray-white matter junctions ofthe brains of 16 rabbits. The stages of brain abscesses were divided into four : early cerebritis (days 1 to 5after inoculation of the organism) ; late cerebritis (days 6 to 14) ; early capsular (days 16 to 21) ; and latecapsular (days 22 to 28). The available MR images showed 14 cases at the stage of early cerebritis, seven at thelate cerebritis stage, three at the early capsular, and one at the late capsular stage. According to the known pathology of brain abscesses and on the basis of both MR imaging and histopathologic findings, the lesions weregrouped according to whether they were found in the central necrotic, border, or peripheral zone. We analyzed the patterns of rim-enhancement (completeness of the rim, thickness, and margin) and the signal intensities of theabscess walls on MR images at each stage. Histopathologic correlation was performed in one case of each stage. We evaluated the presence or absence and degree of infiltration by inflammatory granulation tissue, microhemorrhage, reticulin, collagen, and hemosiderin of the abscess walls. RESULTS: Rim-enhancing lesions were present in threeof 14 cases at the late cerebritis stage, in all three cases at the early capsular, in one at the late capsular, but in none at the early cerebritis stage. The enhancing pattern of the late cerebritis stage was irregular-margined incomplete rim-enhancement, with irregular thickness of the abscess walls (3/3). The enhancing pattern of the capsular stages was well-defined, complete rim-enhancement with uniform thickness of the abscess walls (3/4). The signal intensities of the abscess walls at the late cerebritis and early capsular stages were variable. The late capsular stage was characterized by hypointensity of the abscess wall on both T1- and T2-weighted images. Histopathologically, the capsular stages were distinguished from the late cerebritis stage bythe marked infiltration of reticulin and the presence of collagen in the abscess walls. The most conspicuous pathologic finding distinguishing the late from the early capsular stage was abundant infiltration of the abscess wall by collagen and hemosiderin. CONCLUSION: The enhancing pattern of a brain abscess with mature capsule formation was characterized by a well-defined, complete rim-enhancing abscess wall of uniform thickness. The mature abscess wall was hypointense on both T1- and T2-weighted images, may be explained by marked infiltration bymature collagen and hemosiderin.
