Dexamethasone Administration and Propofol Anesthesia Prevent Postoperative Nausea and Vomiting.
10.4097/kjae.1998.34.3.630
- Author:
Sang Yoon CHO
1
;
Sung Ho CHO
;
Kyoung Hun KIM
;
Dong Won KIM
;
Jong Hun JUN
;
Kyo Sang KIM
Author Information
1. Department of Anesthesiology, Hanyang University, School of Medicine, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Anesthetics, intravenous: propofol;
Antiemetics: dexamethasone;
Complication: nausea, vomiting;
Surgery: tonsillectomy
- MeSH:
Anesthesia*;
Child;
Dexamethasone*;
Enflurane;
Humans;
Incidence;
Nausea;
Nitrous Oxide;
Postoperative Nausea and Vomiting*;
Propofol*;
Tonsillectomy;
Vomiting
- From:Korean Journal of Anesthesiology
1998;34(3):630-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Nausea, vomiting are among the most common postoperative complaints. We compared the effects of dexamethasone with or without propofol to the effects of conventional regimen consisting of enflurane-N2O in the prevention of postoperative nausea and vomiting. METHODS: Eighty healthy children, aged 3~14 yr, undergoing elective tonsillectomy were alldegrees Cated randomly to receive either 67% nitrous oxide and 1.5~2.0% enflurane or 67% nitrous oxide and propofol infusion 6~10 mg/kg/hr for maintenance of anesthesia. Dexamethasone 150 microgram/kg(maximum dose 8mg) or placebo was administered intrvenously(IV) in a double-blinded fashion before surgery. RESULTS: Dexamethasone reduced the overall incidence of vomiting from 45%(control) to 10%, Propofol also reduced from 45% to 15%. Combination of propofol anesthesia and dexamethasone administration reduced from 45% to 10%. CONCLUSIONS: Dexamethasone and propofol markedly decreased vomiting in healthy children after elective tonsillectomy.
