The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study.
10.3346/jkms.2011.26.2.243
- Author:
Li LU
1
;
Beibei WANG
;
Zhongyan SHAN
;
Fengwei JIANG
;
Xiaochun TENG
;
Yanyan CHEN
;
Yaxin LAI
;
Jiani WANG
;
Haibo XUE
;
Sen WANG
;
Chenyan LI
;
He LIU
;
Ningna LI
;
Jiashu YU
;
Liangfeng SHI
;
Xin HOU
;
Qian XING
;
Xue BAI
;
Weiping TENG
Author Information
1. Department of Endocrinology and Metabolism, the First Hospital of China Medical University, Shengyang, P.R. China. shanzhongyan@hotmail.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Thyrotropin;
Total Cholesterol;
Cholesterol, LDL;
Triglyceride;
Cholesterol, HDL
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Cholesterol/blood;
Cholesterol, HDL/blood;
Dyslipidemias/*blood;
Female;
Humans;
Insulin Resistance;
Lipids/blood;
Male;
Middle Aged;
Thyrotropin/*blood;
Triglycerides/blood;
Young Adult
- From:Journal of Korean Medical Science
2011;26(2):243-249
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
