Extranodal Interdigitating Dendritic Cell Sarcoma Presenting in the Pleura: A Case Report.
10.3346/jkms.2011.26.2.304
- Author:
Hye Suk HAN
1
;
Ok Jun LEE
;
Sung nam LIM
;
Jin Young AN
;
Ki Man LEE
;
Kang Hyeon CHOE
;
Ki Hyeong LEE
;
Seung Taik KIM
Author Information
1. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea. stkim@chungbuk.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Dendritic Cell Sarcoma;
Interdigitating;
Pleura
- MeSH:
Adult;
Dendritic Cell Sarcoma, Interdigitating/diagnosis/*pathology;
Fatal Outcome;
Humans;
Male;
Pleura/*pathology;
Pleural Neoplasms/diagnosis/*pathology;
Tumor Markers, Biological
- From:Journal of Korean Medical Science
2011;26(2):304-307
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare neoplasm arising from the antigen-presenting cells of the immune system. This disease usually involves the lymph nodes, and rarely, extranodal sites may be affected. The authors report a case of extranodal IDCS presenting in the pleura. A 32-yr-old man presented with progressive chest pain. Imaging studies showed diffuse pleural thickening with pleural effusion. Morphological and immunohistochemical analysis of an incisional biopsy of the pleura were consistent with a diagnosis of IDCS; tumor cells were positive for S100 and CD45, but negative for CD1a, CD21, CD35, B cell and T cell markers. The patient was administered chemotherapy, but died of progressive disease. Although its incidence is extremely rare, this case suggests that extranodal IDCS should be considered in the differential diagnosis of undifferentiated neoplasms and that immunohistochemical staining be performed using appropriate markers.
