Guillain-Barré Syndrome Caused by Influenza Virus.
10.14776/piv.2016.23.3.236
- Author:
Hyun Gil CHOI
1
;
Gyu Min YEON
Author Information
1. Department of Pediatrics, Kosin University College of Medicine, Busan, Korea. ygmcu@hanmail.net
- Publication Type:Case Report
- Keywords:
Guillain-Barre syndrome;
Influenza, human;
Polymerase chain reaction;
Cerebrospinal fluid
- MeSH:
Antibodies;
Autoimmunity;
Cerebrospinal Fluid;
Child;
Communicable Diseases;
Female;
Guillain-Barre Syndrome*;
Headache;
Humans;
Immunoglobulins;
Influenza A virus;
Influenza, Human*;
Leg;
Magnetic Resonance Imaging;
Neural Conduction;
Neurologic Examination;
Orthomyxoviridae*;
Oseltamivir;
Polymerase Chain Reaction
- From:Pediatric Infection & Vaccine
2016;23(3):236-239
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Guillain-Barré syndrome (GBS) is caused by antecedent infectious diseases in approximately two-thirds of cases. GBS is considered an autoimmune response. Among reported preceding infections, influenza virus is relatively rare. Several reports have identified antibodies related to GBS pathogenesis. However, no case report has described the detection of influenza virus in the cerebrospinal fluid (CSF) of a patient with GBS by polymerase chain reaction (PCR). Here we report the case of a 6-year-old girl who was diagnosed with influenza A 1 week prior and was treated with oseltamivir, after which she visited our hospital for headache and bilateral leg weakness that had persisted for 1 day. We diagnosed her with GBS based on physical and neurologic examination findings, CSF analysis, nerve conduction velocity test results, spinal magnetic resonance imaging, and detection of influenza A virus in her CSF by PCR. She was treated with intravenous immunoglobulin and her symptoms slowly improved. This case report suggests that GBS may be caused by influenza virus through penetration of the CSF.
