Rotavirus-associated neonatal necrotizing enterocolitis.
- Author:
Hyun Joo SEO
1
;
Yu Jin JUNG
;
Soo Kyung PARK
;
Seo Hui CHOI
;
Ji Hyuk LEE
;
Myo Jing KIM
;
Yun Sil CHANG
;
Won Soon PARK
Author Information
- Publication Type:Original Article
- Keywords: Rotavirus infections; Enterocolitis; Necrotizing; Newborn
- MeSH: Birth Weight; Enterocolitis; Enterocolitis, Necrotizing; Gestational Age; Humans; Immunoenzyme Techniques; Incidence; Infant; Infant, Newborn; Pneumoperitoneum; Portal Vein; Retrospective Studies; Rotavirus Infections; Thrombocytopenia
- From:Korean Journal of Pediatrics 2009;52(1):56-60
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced diffe rent clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC). METHODS: Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively. RESULTS: RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age (33.5+/-3.3 weeks vs. 29.3+/-4.4 weeks; P=0.01). There were no differe nces in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical inte rvention differed between the two groups. The number of complications and mortality rates were also similar. CONCLUSION: Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC.
