Maternal Serum Levels of VCAM-1, ICAM-1 and E-selectin in Preeclampsia.
10.3346/jkms.2004.19.5.688
- Author:
Shin Young KIM
1
;
Hyun Mee RYU
;
Jae Hyug YANG
;
Moon Young KIM
;
Hyun Kyong AHN
;
Ha Jung LIM
;
Joong Sik SHIN
;
Hyuk Jun WOO
;
So Yeon PARK
;
Young Mi KIM
;
Jin Woo KIM
;
Eun Hee CHO
Author Information
1. Laboratory of Medical Genetics, Samsung Cheil Hospital and Women`s Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pre-Eclampsia;
Cell Adhesion Molecules;
Vasurlar Cell Adhesion Molecule-1, Intercellular Adhesion Molecule-1, E-Selectin
- MeSH:
Adult;
Biological Markers;
Cell Adhesion Molecules/*blood;
E-Selectin/blood;
Female;
Humans;
Intercellular Adhesion Molecule-1/blood;
Pre-Eclampsia/*blood;
Pregnancy;
Severity of Illness Index;
Solubility;
Vascular Cell Adhesion Molecule-1/blood
- From:Journal of Korean Medical Science
2004;19(5):688-692
- CountryRepublic of Korea
- Language:English
-
Abstract:
Endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. The aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) in sera of normal and preeclamptic pregnancies. We studied the serum levels of sVCAM-1, sICAM-1 and sE-selectin in normal pregnant women (n=63), mild preeclampsia (n=33) and severe preeclampsia (n=82). Concentrations of soluble adhesion molecules were determined with enzyme-linked immunoassay (ELISA). Serum concentrations of sVCAM-1 were significantly higher in both mild (p=0.004) and severe preeclampsia (p=0.000) than normal pregnancy. There were also significant differences in sVCAM-1 levels between mild and severe preeclampsia (p=0.002). sICAM-1 levels of severe preeclampsia were statistically different from those of normal pregnancy (p=0.038). Levels of sE-selectin were elevated in both mild (p=0.011) and severe preeclampsia (p=0.000) compared to normal pregnancy, but no statistical difference between the mild and severe preeclampsia (p=0.345). These results suggest that all three soluble adhesion molecules are increased in severe preeclampsia, and sVCAM-1 among them may be useful in predicting the severity of preeclampsia.
