Proton Magnetic Resonance Spectroscopic Changes of the Primary Motor Cortex and Supplementary Motor Area in Hemiparetic Patients with Corticospinal Tract Injury due to Deep Intracerebral Hematoma.
10.3346/jkms.2004.19.5.744
- Author:
Dong Joon YANG
1
;
Byung Chul SON
;
Hyun Man BAIK
;
Sang Won LEE
;
Jae Hoon SUNG
;
Bo Young CHOE
Author Information
1. Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. sbc@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Hemiparesis;
Paresis;
Cerebral Hemorrhage;
Magnetic Resonance Spectroscopy;
Motor Cor-tex;
Internal Capsule;
N-acetylaspartate
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Aspartic Acid/*analogs & derivatives/metabolism;
Basal Ganglia Hemorrhage/metabolism/*pathology;
Creatine/metabolism;
Female;
Humans;
*Magnetic Resonance Spectroscopy;
Male;
Middle Aged;
Motor Cortex/metabolism/*pathology;
Paresis/metabolism/*pathology;
Phosphocreatine/metabolism;
Protons;
Pyramidal Tracts/metabolism/*pathology
- From:Journal of Korean Medical Science
2004;19(5):744-749
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to investigate the metabolic changes in the motor and motor association cortices following axonal injury in the internal capsule that was caused by deep intracerebral hematoma. Using proton magnetic resonance spectroscopy (1H MRS), the authors studied the primary motor cortices (M-1) and sup-plementary motor areas (SMA) of 9 hemiparetic patients with documentable hemi-paresis of varying severity, and we studied 10 normal volunteers as controls. To measure the M-1 and SMA biochemical changes, 4 separate single volumes of inter-est(VOIs) were located bilaterally in the affected and unaffected hemisphere (AH and UH).1H MRS provided a neuronal and axonal viability index by measuring levels of N-acetylaspartate (NAA) and creatine/phosphocreatine (Cr). The M-1/SMA NAA/Cr ratios of the AH and UH in patients, and the AH and normal volunteers were com-pared. The NAA/Cr ratios of the M-1 and SMA in AH, and the SMA in UH were sig-nificantly lower than those of normal volunteers. These 1H MRS findings indicate that axonal injury in the descending motor pathway at the level of internal capsule could induce metabolic changes in the higher centers of the motor pathway.
