Malignant Gastrointestinal Stromal Tumor of the Gallbladder.
10.3346/jkms.2004.19.5.763
- Author:
Jong Kyung PARK
1
;
Seung Hye CHOI
;
Seong LEE
;
Ki Ouk MIN
;
Sang Seob YUN
;
Hae Myung JEON
Author Information
1. Department of Surgery, St. Paul's Hospital, Korea, The Catholic University of Korea School of Medicine, Seoul, Korea. ssyun@catholic.ac.kr
- Publication Type:Case Report ; Review
- Keywords:
Gastrointestinal Stromal Tumors;
Antigen, cd117;
Proto-Oncogene Protein c-kit;
Gallbladder Neoplasms
- MeSH:
Aged;
Female;
Gallbladder Neoplasms/genetics/metabolism/*pathology;
Gastrointestinal Stromal Tumors/genetics/metabolism/*pathology;
Humans;
Proto-Oncogene Protein c-kit/genetics/metabolism
- From:Journal of Korean Medical Science
2004;19(5):763-767
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastrointestinal stromal tumors (GISTs) of the gallbladder are representative of an extremely rare group of tumors. We have encountered a patient with a malignant GIST of the gallbladder and presented it with a review of some articles. A 72-yr-old woman initially presented with right upper quadrant abdominal pain, fever and chills. Emergency cholecystectomy was performed under the impression of gallbladder empyema. Liver metastasis was found at 7 months postoperatively and the patient expired 9 months after the surgery. At the time of cholecystectomy, the gallbladder showed a necrotic serosal surface with an irregular thickened wall. A mass, 6 cm in length and 3 cm in width, encircled the whole wall of the neck and upper body of the gallbladder. Microscopic findings revealed frequent mitotic figures (more than 20/50 HPF) and tumor necrosis. Hyperchromatic, pleomorphic and spindle shaped neoplastic cells that were arranged in a pattern of short fascicles infiltrated the entire layer of the gallbladder. The tumor cells were immunoreactive for CD117 antigen (c-kit protein) and vimentin. They were negative for desmin, smooth muscle actin and S-100 protein. Mutations of the c-kit proto-oncogene were not found in this case. These findings were sufficient to provide enough clinical, histopathological and immunohistochemicalevidence in diagnosing our case as a malignant GIST.
