Relationship Between Poly (A) Microsatellite in Vitamin D Receptor Gene, and Bone Mineral Density in Postmenopausal Korean Women.
- Author:
Jung Gu KIM
1
;
Jae Hee KWON
;
Seok Hyun KIM
;
Young Min CHOI
;
Shin Yong MOON
;
Jin Yong LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Postmenopausal women;
Poly (A) polymorphism;
BMD;
Vitamin D3
- MeSH:
Absorptiometry, Photon;
Alkaline Phosphatase;
Alleles;
Bone Density*;
Cholecalciferol;
Enzyme-Linked Immunosorbent Assay;
Female;
Femur;
Femur Neck;
Genotype;
Humans;
Microsatellite Repeats*;
Osteocalcin;
Prevalence;
Receptors, Calcitriol*;
Spine;
Vitamin D*;
Vitamins*
- From:Korean Journal of Obstetrics and Gynecology
2003;46(4):795-801
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate a poly (A) microsatellite in vitamin D receptor (VDR) gene and to evaluate its relationship with bone mineral density (BMD) in postmenopausal Korean women. METHODS: The poly (A) polymorphism was analyzed in 417 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin and 1,25 (OH)2 vitamin D3 levels were measured by enzyme linked immunosorbent assay and immmunoassay and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. RESULTS: When alleles of poly (A) microsatellite were classified into two groups, long (L: A18-22) and short (S: A12-17), based upon the length of the repeat, the prevalence of SS was 1.4%, LS 10.1%, and LL 88.5%. There was a significant correlation between BMD and poly (A) polymorphism. BMD at the femoral neck and trochanter in LS genotype was significantly lower than that in LL genotype. LL genotype was more prevalent in women with normal BMD compared with women with low bone mass while LS genotype was more prevalent in the latter group. There were no significant associations between the adjusted levels of the bone markers, 1,25 (OH)2 vitamin D3 and poly (A) genotypes. CONCLUSION: The VDR gene poly (A) polymorphism is one of genetic factors which may affect BMD in Korean women.
