Effects of mitomycin C on delayed adjustment in experimental strabismus surgery.
- Author:
Se Oh OH
1
;
Bong Leen CHANG
;
Jaeheung LEE
Author Information
- Publication Type:Original Article
- Keywords: adjustable strabismus surgery; delayed adjustment; postoperative adhesions; mtomycin C
- MeSH: Administration, Topical; Animals; Chemotherapy, Adjuvant; Conjunctiva/drug effects; Mitomycin/administration & dosage/*pharmacology; Oculomotor Muscles/drug effects/pathology/*surgery; Ophthalmic Solutions; Postoperative Complications/prevention & control; Rabbits; Sclera/drug effects; Strabismus/drug therapy/pathology/*surgery; Suture Techniques; Tissue Adhesions/prevention & control
- From:Korean Journal of Ophthalmology 1995;9(1):51-58
- CountryRepublic of Korea
- Language:English
- Abstract: In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
