Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?.
10.3904/kjim.2013.28.2.206
- Author:
Seung Geun LEE
1
;
Ji Min KIM
;
Sun Hee LEE
;
Kye Hyung KIM
;
Ji Hye KIM
;
Ji Won YI
;
Woo Jin JUNG
;
Young Eun PARK
;
Seong Hu PARK
;
Joung Wook LEE
;
Seung Hoon BAEK
;
Jun Hee LEE
;
Geun Tae KIM
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Arthritis, rheumatoid;
Metabolic syndrome X;
Insulin resistance;
Cardiovascular diseases
- MeSH:
Adult;
Aged;
Arthritis, Rheumatoid/diagnosis/*epidemiology;
Biological Markers/blood;
Case-Control Studies;
Chi-Square Distribution;
Cross-Sectional Studies;
Female;
Humans;
Insulin Resistance;
Linear Models;
Logistic Models;
Metabolic Syndrome X/blood/diagnosis/*epidemiology;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
Prevalence;
Republic of Korea/epidemiology;
Risk Assessment;
Risk Factors;
Sex Factors;
Young Adult
- From:The Korean Journal of Internal Medicine
2013;28(2):206-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evaluate risk factors for MetS and increased HOMA-IR in patients with RA. METHODS: In a cross-sectional setting, 84 female patients with RA and 109 age-matched healthy female subjects were consecutively recruited at a university-affiliated rheumatology center in South Korea. MetS was defined according to the Third Report of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP III) 2004 criteria. RESULTS: The frequency of MetS did not differ significantly between patients with RA (19%) and healthy subjects (15.6%, p = 0.566), although patients with RA had a higher HOMA-IR compared with healthy subjects (p < 0.001). Patients with RA met the NCEP-ATP III 2004 criteria for high blood pressure more often than healthy subjects (44% vs. 19.3%, p < 0.001), and low high density lipoprotein cholesterol was more prevalent in healthy subjects (33%) than in patients with RA (14.3%, p = 0.004). Although no obvious risk factors for the presence of MetS were identified in patients with RA, higher serum C-reactive protein and disease activity score assessed using the 28-joint count for swelling and tenderness-erythrocyte sedimentation rate significantly contributed to a higher HOMA-IR. CONCLUSIONS: Despite their increased insulin resistance, South Korean women with RA did not have a significantly higher frequency of MetS compared with that in healthy subjects.
