Pretreatmet with 5% lidocaine patch reduces cannula-induced and propofol-induced pain: a randomized, double-blind, placebo-controlled study.
10.4097/kjae.2016.69.5.468
- Author:
Jung Min HONG
1
;
Hyeon Jeong LEE
;
Ah Reum CHO
;
Ji Seok BAIK
;
Do Won LEE
;
Young Tae JI
;
Ki Chan YOO
;
Hae Kyu KIM
Author Information
1. Department of Anesthesia and Pain Medicine, Pusan National University Hospital, Busan, Korea. lhjksk@pusan.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Cutaneous administration;
Lidocaine;
Pain;
Propofol
- MeSH:
Administration, Cutaneous;
Anesthesia;
Catheterization;
Double-Blind Method;
Humans;
Incidence;
Lidocaine*;
Methods;
Propofol
- From:Korean Journal of Anesthesiology
2016;69(5):468-473
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to determine the efficacy of 5% lidocaine patch in reducing propofol-induced pain and cannula-induced pain. METHODS: In a randomized, double-blind study, 126 patients were divided into one of three groups: pretreatment with a 5% lidocaine patch (Lidotop®) and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group A); pretreatment with a placebo patch and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group B); or pretreatment with a placebo patch and premixed 2 ml of 2% lidocaine (40 mg) with 1.5 mg/kg of 1% propofol (Group C) for induction of anesthesia. Pain severity was evaluated on a four-point verbal rating scale during intravenous cannulation, propofol injection, and 24 h after the operation (recall). RESULTS: Eighteen patients (47.4%) in Group A complained of cannula-induced pain compared with 35 (94.6%) in Group B and 36 (94.7%) in Group C (P < 0.001). Group A patients showed significantly lower incidence of propofol-induced pain and recall of propofol-induced pain compared with Group B (P < 0.001 and P = 0.01), whereas there was no difference compared with Group C. CONCLUSIONS: Preoperative transdermal administration of 5% lidocaine patch is an effective and simple method in reducing propofol-induced pain as well as cannula-induced pain.
