Study on pilot assay in manufacture of film coated tablet of ketoprofen with prolonged action
- Author:
Lai Thi Nguyen
- Publication Type:Journal Article
- Keywords:
ketoprofen
- MeSH:
Ketoprofen;
Cyclooxygenase Inhibitors;
tablets;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2001;298(2):14-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
To obtain a prolonged-action dosage form of Ketoprofen, a technique for delaying drug release from insoluble inert matrix of ethyl cellulose was evaluated. It was incorporated with excipients such as lactose, starch, hydroxy propyl methyl cellulose. influence of lubricants on release profiles was also investigated. The best result was obtained from the formula that consists of ethyl cellulose, lactose, starch, hydroxy propyl methyl cellulose, magnesium stearate, talc, aerosil (appropriate rate) and is coated with Eudragit L 100 (1mg/cm2)
