Evaluation and comparison in vitro solubility and in vivo absorption of ketoconazole 200mg tablets with nizoral tablets 200mg
- Author:
Ma Tuc Tran
- Publication Type:Journal Article
- Keywords:
ketoconazole
- MeSH:
Ketoconazole;
Imidazoles;
tablets;
Pharmaceutical Preparations;
therapeutics
- From:Pharmaceutical Journal
2001;298(2):18-22
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In this study, we present the results obtained in an in vitro dissolution test and in vivo bioavailability study of some ketoconazol preparations (Ketoconazol – Traphaco, Vietnam and Nizoral – Janssen, Belgium). Rabbit plasma ketoconazol concentrations were measured by reverse phase HPLC, UV detection at 244 nm. Ketoconazol percentage released from the preparations was automatically measured using a paddle type dissolution tester with a Beckman spectrophotometer. The obtained results showed that there was no remarkable difference in bioavailability and dissolution between the two preparations (Ketoconazol – Traphaco and Nizoral - Janssen)
