The Significance of C-erbB-2 Oncoprotein Expression as a Prognostic Predictor in Human Breast Cancer.
10.4048/jkbcs.1998.1.1.69
- Author:
Ki Jae PARK
1
;
Se Hoon CHO
;
Young Hoon KIM
;
Ghap Joong JUNG
;
Sang Soon KIM
;
Sook Hee HONG
Author Information
1. Department of Surgery, Doug-A University College of Medicine, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
C-erbB-2;
Breast Cancer
- MeSH:
Breast Neoplasms*;
Breast*;
Humans*;
Lymph Nodes;
Neoplasm Metastasis;
Paraffin
- From:Journal of Korean Breast Cancer Society
1998;1(1):69-78
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The immunohistochemical staining for the C-erbB-2 oncoprotein was performed on sections from paraffin embedded tissue blocks of 96 primary breast cancer patient who underwent operation in our hospital. in order to evaluate the significances as a prognostic factor in the human breast cancer. We investigated the correlation between traditional prognostic factors-patient age, primary tumor size, axillary lymph node metastasis, pathological grade, hormonal receptors (ER &PR)-and C-erbB-2 oncoprotein overexpression. The overall rates of positive staining of C-erbB-2 oncoprotein was 37.5% (36/96). Statistically, the C-erbB-2 positive staining was not correlated with patient age, primary tumor size, axillary lymph node involvement, hormonal receptors, But the high pathologic grade was correlated with C-erbB-2 oncoprotein overexpression and appeared statistically significant (p=0.010). The C-erbB-2 oncoprotein appeared to have prognostic significance in human breast cancer the result.
