A Case of Chronic Active Hepatitis Developed in Patient with Psoriasis after Long-term Methotrexate Treatment.
- Author:
Dae Hyun KIM
;
Jae Hyun JO
;
Min Su KEUM
;
Seong Gon CHOI
;
Chang Hyeong LEE
;
Young Oh KWEON
;
Sung Kook KIM
;
Yong Whan CHOI
;
Joon Mo CHUNG
- Publication Type:Case Reports
- Keywords:
Methotrexate;
Chronic active hepatitis;
Psoriasis
- MeSH:
Arthritis, Rheumatoid;
Fibrosis;
Hepatitis;
Hepatitis, Chronic*;
Humans;
Korea;
Methotrexate*;
Psoriasis*
- From:The Korean Journal of Hepatology
1997;3(1):78-84
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methotrexate (MTX) has been widely used in the treatment of psoriasis and rheumatoid arthritis. But prolonged use of MTX can induce hepatic fibrosis and even cirrhosis. To date, in Korea, there have been very few reports on hepatotoxicity due to MTX, and no report on biopsy-proven chronic active hapatitis. We report one patient who developed chronic acitve hepatitis while taking long-term daily dose of MTX(10mg per day) for psoriasis for a prolonged period.
