Cefepime Neurotoxicity in Patients with Renal Insufficiency.
10.5535/arm.2012.36.1.159
- Author:
Seon Yu KIM
1
;
In Sik LEE
;
Seung Lee PARK
;
Jongmin LEE
Author Information
1. Department of Rehabilitation Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, Korea. mdlis@nate.com
- Publication Type:Case Report
- Keywords:
Cefepime;
Neurotoxicity;
Renal failure
- MeSH:
Cephalosporins;
Humans;
Kidney;
Renal Insufficiency
- From:Annals of Rehabilitation Medicine
2012;36(1):159-162
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients with renal impairment who developed neurotoxicity including lethal outcome after treatment with cefepime.
