Effect of Autologous Peripheral Blood Mononuclear Cell Transplantation on Patients with Chronic Ischemic Limb.
- Author:
Hayng Ran LEE
1
;
Oh Jung KWON
Author Information
1. Division of Vascular Surgery, Department of Surgery, College of Medicine, Hanyang University, Seoul, Korea. ojkwon@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Peripheral blood mononuclear cell;
Peripheral arterial disease
- MeSH:
Ankle;
Atherosclerosis;
Cell Transplantation*;
Extremities*;
Femoral Artery;
Foot;
Granulocyte Colony-Stimulating Factor;
Granulocytes;
Humans;
Perfusion;
Peripheral Arterial Disease;
Transplants*;
Ulcer
- From:Journal of the Korean Society for Vascular Surgery
2007;23(1):1-5
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In the present study, the effects of autologous peripheral blood mononuclear cells (PBMNC) transplantation after granulocyte colony stimulation factor (G-CSF)-induced mobilization was investigated in patient with severe peripheral arterial disease. METHOD: 4 cases were enrolled: 3 cases are atherosclerosis obliterance and 1 case is thromboangitis obliterance. Following administration of G-CSF (10microgram/kg, maximum 600microgram), 4 times for 4 days. PBMNC were harvest and injected via femoral artery to vascular foot bed. RESULT: No serious complication was observed during G-CSF injection, harvest and injection. Improvement in the ankle brachial pressure index was seen in all patients at 4 weeks and ischemic ulcer improved in 2 of 3 patients. Using of pain control decreased in all cases and increased blood flow at 99 m-Tc perfusion scan in 2 of 2 patients. CONCLUSION: These favorable outcomes strongly suggest a therapeutic impact of transplantation PBMNC in clinical setting.
