A Case of Pyoderma Gangrenosum with Ulcerative Colitis Treated with Mesalazine.

Author: Jae In LEE ¹ ; Hyun Jeong PARK ; Jun Young LEE ; Baik Kee CHO
Author Information

1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. jylee@catholic.ac.kr
Publication Type:Case Report
Keywords: Mesalazine; Pyoderma gangrenosum; Ulcerative colitis
MeSH: Adult; Cheek; Colitis, Ulcerative; Female; Humans; Inflammatory Bowel Diseases; Mesalamine; Prednisolone; Pyoderma; Pyoderma Gangrenosum; Skin; Ulcer
From:Annals of Dermatology 2010;22(4):422-425
CountryRepublic of Korea
Language:English
Abstract: Pyoderma gangrenosum (PG) manifests as recurrent deep ulceration of the skin and PG is associated with a variety of disorders. Approximately 30% of the cases of PG develop in patients with inflammatory bowel disease. A 34-year-old woman presented with a one-week history of recurrent ulcers on the right cheek and back. She was diagnosed with ulcerative colitis (UC) 4 years previously and with PG 1 year previously. The clinical course of the skin lesions followed the status of her UC. The patient's skin lesions and bowel symptoms were not improved with prednisolone. After she was started on mesalazine, we observed rapid resolution of skin lesions and bowel symptoms. Herein, we report a case of recurrent PG with UC, and we discuss the possible association between these two conditions, and the efficacy of mesalazine therapy for the treatment of PG combined with UC.