The effect of topical application with steroid and cyclosporine on oral lichen planus patients.
- Author:
Soon Min HONG
1
;
Sung Jin PARK
;
Jee Hyun PARK
;
Pil Young YUN
;
Hoon MYOUNG
;
Hong Seop KHO
;
Sung Chang CHUNG
;
Jong Ho LEE
;
Myung Jin KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University. myungkim@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Oral lichen planus;
Steroid;
Cyclosporine;
Immunosupressant
- MeSH:
Burns;
Cyclosporine*;
Erythema;
Humans;
Lichen Planus, Oral*;
Sensation
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2004;30(3):203-210
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.
