A Randomized Comparison of Cilostazol Versus Ticlopidine Therapy After Elective Coronary Stent Implantaion.
10.4070/kcj.2001.31.8.780
- Author:
Jin Ho SONG
1
;
Chul YOON
;
IL RHEE
;
Jun Yong JUNG
;
Kil Hyun JO
;
Doo Il KIM
;
Dong Soo KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Inje University, Paik Hospital, Pusan, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Coronary artery stent;
Restenosis;
Cilostazol;
Ticlopidine
- MeSH:
Aspirin;
Busan;
Coronary Vessels;
Death;
Exanthema;
Follow-Up Studies;
Headache;
Humans;
Myocardial Ischemia;
Phenobarbital;
Stents*;
Thrombocytopenia;
Ticlopidine*
- From:Korean Circulation Journal
2001;31(8):780-787
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Percutaneous transluminal coronary angioplasty(PTCA) is a widely acceptable treatment for ischemic heart disease. Restenosis after successful PTCA, which develops in 20~30% of all patients, remains a serious late complication. This study was to evaluate the efficacy of cilostazol for the prevention of stent restenosis compared with ticlopidine. MATERIALS AND METHOD: Fifty three patients underwent coronary stent implantation were divided in to as group A(n=25) receiving 100mg aspirin and 200mg cilostazol and group B(n=28) receiving 100mg asprine and 500mg ticlopidine from Sep 1998 and Feb 1999 at Pusan Paik Hospital, Inje University. Clinical and laboratory evaluations were preformed at regular interval. RESULT: There were no differences in baseline characteristics between the two groups. Coronary artery restenosis was observed in 5(20.8%) in group A and 8(26%) in group B respectively, which were not statistically significant (p=NS). Minimal luminal diameter was 2.10+/-0.89mm in group A and 1.93+/-0.65mm in group B (p=NS). Two patients in group A had headache, while 6(21.4%) patients of group B developed side effects including thrombocytopenia in 2 patients, skin rash in 2 patents . There was no cardiac death during the follow-up period. CONCLUSION: Aspirin plus cilostazol may be safer and equally antithrombotic regimen compared results to aspirin plus ticolpidine after elective coronary stent implantation.
