Glucose metabolism in chronic hepatitis B infection-acute insulin response and glucose disappearance rate to intravenous glucose.
- Author:
Chan Soo SHIN
;
Kyoung Soo PARK
;
Seong Yeon KIM
;
Hong Kyu LEE
;
Chang Soon KOH
;
Young Bae KIM
- Publication Type:Original Article
- Keywords:
Chronic hepatitis B;
Intravenous glucose;
Insulin resistance;
Insulin secretion
- MeSH:
Body Mass Index;
C-Peptide;
Diabetes Mellitus;
Glucose Intolerance;
Glucose Tolerance Test;
Glucose*;
Hepatitis B, Chronic*;
Hepatitis, Chronic*;
Humans;
Insulin Resistance;
Insulin*;
Korea;
Liver Cirrhosis;
Liver Diseases;
Metabolism*;
Natural History;
Plasma
- From:Journal of Korean Society of Endocrinology
1997;12(2):275-282
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Glucose intolerance and diabetes mellitus are frequently observed in chronic liver disease. However, the causal relationships between these two are difficult to prove. Chronic hepatitis B infection, which is prevalent in Korea, is thought to be a good model to study the natural history of abnormal glucose metabolism in chronic liver disease because many patients with chronic hepatitis B infection eventually progress to liver cirrhosis. METHODS: In order to evaluate glucose metabolism in chronic hepatitis B infection, we did intravenous glucose tolerance test in patients with chronic hepatitis B and age, sex and body mass index matched controls and compared the first phase insulin response and glucose disappearance rates between 2 groups. RESULTS: Patients with chronic hepatitis B showed lower glucose disappearance rate and higher plasma insulin and C-peptide area (0-10min after iv glucose) than controls. Patients with decreased glucose disappearance rate had higher AST level and decreased plasma C-peptide area (0-10min). CONCLUSION: Most of the patients with chronic hepatits B infection is associated with insulin resistance and compensatory increase in the first phase insulin secretion. Inadequate insulin secretion may contribute to decreased glucose disappearance rate in these patients.
