Evaluation on the bone regenerative capacity of hyaluronic acid applied poly (D,L-lactic-co-glycolic acid) membranes in rabbit calvarial defect.
10.4047/jkap.2010.48.2.158
- Author:
Nam Sook KIM
1
;
Kwi Dug YUN
;
Mong Sook VANG
;
Hong So YANG
;
Hyun Phil LIM
;
Sung Soo KANG
;
Sang Won PARK
Author Information
1. Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Korea. psw320@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Poly (D,L-lactic-co-glycolic acid);
Hyaluronic acid;
Membrane;
Bone regeneration
- MeSH:
Bone Regeneration;
Collagen;
Connective Tissue;
Fats;
Hyaluronic Acid;
Lactic Acid;
Membranes;
Osteogenesis;
Polyglycolic Acid;
Rabbits;
Skull
- From:The Journal of Korean Academy of Prosthodontics
2010;48(2):158-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The objective of the present study was to histologically evaluate durability and bone regeneration capacity of new synthetic membranes in comparison to clinically available collagen membrane. MATERIAL AND METHODS: To the skulls of 12 rabbits, we created 4 bone defects of 6 mm in diameter on each of them. Each of defects were covered with at least one of 5 membranes: No membrane, Collagen (Ossix(TM)), PLGA, HA-coated-PLGA and HA-PLGA/PLGA. After 4, 8, 12 weeks, we cut the skulls and dyed with H-E. And then, the histologic observation was done. RESULTS: In current study, the control group which did not use the membrane showed bone regeneration at 12 weeks and covered the bone defect partially. New bones were formed through the underneath of endocranium, and the upper defect was filled with connective tissues and fats. Collagen membrane (Ossix(TM)) showed new bones after 4 weeks, and they were formed through the membrane which maintained until 12 weeks. PLGA, HA-coated-PLGA, HA-PLGA/PLGA showed bone regeneration after 4 weeks and after 8 weeks, they mostly filled defects. At 12 weeks, we could find new bones and previous bones almost look alike and also, they united well. Membranes were unnoticeable after 4 weeks and were absorbed. CONCLUSION: Bone formation and maturation of PLGA, HA-coated-PLGA and HA-PLGA/PLGA were faster than the control group. They showed no difference on the application of HA and after 4 weeks, they were absorbed.
