Herpes Simplex Esophagitis Following Cadaveric Renal Transplantation.
- Author:
Sang Hyuck SEO
1
;
Sang Su LEE
;
Sung Bae PARK
;
Young Woo KANG
;
Hyun Chul KIM
;
Won Hyun CHO
;
Hyung Tae KIM
;
Chaol Hee PARK
;
Kun Young KWON
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Renal transplantation;
Herpes simplex;
Herpetic esophagitis
- MeSH:
Allografts;
Biopsy;
Cadaver*;
Cyclosporine;
Deglutition Disorders;
Epithelial Cells;
Esophagitis*;
Esophagoscopy;
Esophagus;
Female;
Herpes Simplex*;
Herpesvirus 1, Human;
Humans;
Immunocompromised Host;
Immunosuppression;
Kidney;
Kidney Transplantation*;
Mouth;
Nausea;
Prednisolone;
Prognosis;
Proteinuria;
Steroids;
Tissue Donors;
Ulcer
- From:The Journal of the Korean Society for Transplantation
1999;13(1):177-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Herpes simplex esophagitis usually occurs in immunocompromised or severely debilitated patients. Odynophagia and dysphagia are major symptoms and the prognosis of immunocompromised patients is variable. We present the case of a cadeveric donor renal transplantation recipient who developed herpes simplex esophagitis shortly after anti-rejection therapy. A 43-years-old female had cadaveric renal transplantation and following treatment with cyclosporine, prednisolone, mycophenolate mofetile. Twelve months later, renal insufficieny and proteinuria were developed. Allograft kidney biopsy showed some evidence of acute rejection. She was treated with 3 successive days of intravenous methylpredinisolone (500 mg/d) therapy and continued tapering of steroids. Two weeks later, she had oral cavity ulceration, odynophagia, dysphagia, epigastric pain, and nausea. Esophagoscopy reveals multiple confluent ulceration in the whole part of esophagus and biopsies showed the epithelial cell were enlarged with prominent nuclei. Immunohistochemically, the epithelial cell were positive with a monoclonal antibody to herpes simplex virus type 1. Treatment was started on intravenous ayclovir and changed to oral agent for 10 days. After treatment, her symptoms and repeat endoscopic findings were improved.
