Significance of Non-erosive Minimal Esophageal Lesions in Gastro-esophageal Reflux Disorder.
- Author:
Sung Pyo HONG
1
;
Pil Won PARK
;
Seong Gyu HWANG
;
Kwang Hyun KO
;
Sun Young KWAK
;
Se Hyun KIM
;
Kye Sook KWON
;
Yong Woon SHIN
;
Ji Kon RYU
;
Kwang Hyun RYU
;
Sang Jong PARK
;
Wook Hee WON
;
Hyo Min YOO
;
Hyung Mee BAE
;
Min Jung PARK
;
Yeol Keun WOO
;
Kyung Chul KIM
;
Kyung Hee KIM
;
Seon Hwa NA
;
Jung Wan KIM
Author Information
1. Department of Internal Medicine, Pochon CHA University, Bundang, Korea. sphong@cha.ac.kr
- Publication Type:Original Article ; Controlled Clinical Trial ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Gastro-esophageal Reflux Disease;
Endoscopes;
Gastrointestinal
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
Adult;
Aged;
Aged, 80 and over;
Anti-Ulcer Agents/*therapeutic use;
Benzimidazoles/*therapeutic use;
Enzyme Inhibitors/*therapeutic use;
Esophageal Diseases/*pathology;
Female;
Follow-Up Studies;
Gastroesophageal Reflux/drug therapy/epidemiology/*pathology;
Humans;
Korea/epidemiology;
Male;
Middle Aged;
Omeprazole/*analogs & derivatives/therapeutic use;
Prospective Studies;
Proton-Translocating ATPases/*antagonists & inhibitors;
Treatment Outcome
- From:The Korean Journal of Internal Medicine
2004;19(2):93-98
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive minimal lesions at the lower esophagus and gastro-esophageal reflux disorder. METHODS: Patients were asked to answer a symptom questionnaire. The endoscopic findings were either graded by LA classification or recorded as non-erosive minimal lesions. Patients with minimal lesions were treated with rabeprazole or a placebo and responses were evaluated at weeks 1 and 4. RESULTS: In 8 centers, 3454 patients were screened. In patients with heartburn or acid regurgitation as the most bothersome symptom, 23.7% had endoscopy negative reflux disorder, 40.1% showed minimal lesions, and 36.2% had mucosal break esophagitis. Thirty-four percent of patients with minimal lesions and 39.1% of patients with LA 'grade A' mild esophagitis reported typical reflux symptoms as their main symptom. In patients with minimal lesions, medication with rabeprazole reduced symptoms significantly at weeks 1 and 4, but not with the placebo. CONCLUSION: Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive reflux esophagitis, and reflux symptoms were improved with a short-term proton pump inhibitor. Thus, non-erosive minimal esophageal lesion constitutes a great part of gastro-esophageal reflux disorder.
