Nail Changes During Docetaxel Containing Combination Chemotherapy.
- Author:
In Sook WOO
1
;
Kon Ho SHIM
;
Gi Young KIM
;
Myung Ah LEE
;
Jin Hyoung KANG
;
Young Seon HONG
;
Kyung Shik LEE
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. insookwoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Nail;
Toxicity;
Taxane
- MeSH:
Antimetabolites, Antineoplastic/administration & dosage;
Antineoplastic Agents, Phytogenic/administration & dosage/adverse effects;
Antineoplastic Combined Chemotherapy Protocols/*adverse effects;
Deoxycytidine/administration & dosage/analogs & derivatives;
Dose-Response Relationship, Drug;
Female;
Fluorouracil/analogs & derivatives;
Humans;
Lymphatic Diseases/drug therapy;
Middle Aged;
Nail Diseases/*chemically induced;
Stomach Neoplasms/drug therapy;
Taxoids/*administration & dosage/*adverse effects
- From:The Korean Journal of Internal Medicine
2004;19(2):132-133
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nail toxicity following systemic chemotherapy is common. Onychopathy during the period of neutropenia following chemotherapy may cause subungual abscesses and serious infection. Despite taxoid-related toxicity being increasingly reported since 2000, there are still phase II systemic chemotherapy studies using taxoid that have never mentioned nail changes. Recently, new criteria for the evaluation of nail toxicity have been suggested. The present report is the first of its kind, in Korea, to describe a case of docetaxel-associated onychopathy, which improved following a reduction in the docetaxel dose.
